Allergan Aesthetics

Ms Mabel Chan

mabel.chan@allergan.com

2610 5823

MAXLYTICS Limited

Ms Fiona Cheung

info@maxlytics.io

3709 2787

^Based on a search of published clinical studies of injectable HA treatments in March 2023. A duration of 9 months of skin hydration was established with SKINVIVE?.¹¹

* Skin hydration was measured using the MoistureMeterD instrument with the XS 5 and S 15 probes (depth of effective measurement: 0.5 and 1.5 mm, respectively).¹⁰

?Instrument measures of skin hydration, smoothness, and skin deformation parameters were performed on the cheek, forehead, and neck of one side of the face on Day 0 and at 30 days after initial treatment (before touch up), Months 1, 4, 6, and 9 after the last treatment, and Month 1R. Skin hydration was measured using the MoistureMeterD instrument (n=131) with the XS 5 and S 15 probes (depth of effective measurement: 0.5 and 1.5 mm, respectively) and top-up treatment administered at Day 30 (n=31). ¹⁰

§Lasting up to 9 months as reported by 63% of patients. As reported by patients (127/131) in a composite satisfaction score, which includes how radiant their facial skin looked.¹

‖ Lasting up to 9 months as reported by 55.1% of patients. As reported by patients (127/131) in a composite satisfaction score, which includes how smooth their facial skin looked.¹

**Lasting up to 9 months as reported by 55.9% of patients. As reported by patients (127/131) in a composite satisfaction score, which includes how their pores looked.¹

¶ Lasting up to 9 months as reported by 67.7% of patients. As reported by patients (127/131; 3 subjects did not respond) in a composite satisfaction score, which includes satisfaction with their skin's tone (colour).¹

?Lasting up to 9 months as reported by 64.6% of patients. As reported by patients (127/131) in a composite satisfaction score, which includes how clear their facial skin looked.¹

??Subjects completed the FACE-Q Satisfaction With Skin scale at baseline (Day 0, before treatment), Months 1, 4, 6, and 9 (before repeat treatment, if received), and Month 1 after the repeat treatment (n=131; n=62 received repeat treatment). The Satisfaction With Skin scale is a validated patient-reported outcome instrument designed to assess the impact of treatment from the subject's perspective. The scale comprises 12 questions about satisfaction with different facial skin attributes (e.g. smoothness, clearness, radiance). Responses are rated on a 4-point scale (1: very dissatisfied, 4: very satisfied). Scores for each item.¹

References:
1. Ogilvie P et al. J Cosmet Dermatol. 2020;19(5):1065–1070

2. Clin Cosmet Investig Dermatol. 2022 Mar 10;15:411–426

3. SKINVIVE® by Juvéderm® is FDA approved. U.S. Food and Drug Administration, Department of Health & Human Services. SKINVIVE by Juvéderm approval letter P110033/S059, May 2023. 

4. SKINVIVE® by Juvéderm® is CE approved. European Commission, hyaluronic acid based medical devices. EC certificate number: 3824296CE05

5. Allergan Aesthetics. Data on File. REF-108642. JUVÉDERM®, the world's leading brand of hyaluronic acid facial fillers claim. Mar 2023.

6. Allergan Unpublished Data. INT-VOT-2050006. Juvederm VOLITE laboratory testing: hydration and elasticity, mouldability, tissue integration, spreadability. May 2020.

7. Purnamawati S et al. Clin Med Res. 2017;15(3-4);75–87

8. Akinbiyi T et al. Plast Reconstr Surg Glob Open. 2020;8(10):e2763.

9. Lipko-Godlewska S et al. Clin Cosmet Investig Dermatol. 2021;14:169–178.

10. Niforos F et al. Clin Cosmet Investig Dermatol. 2019;12:791–798.

11. SKINVIVE® by Juvéderm® DFU. 20074348. Revision 2022.09.30.

12. Safa M et al. Clin Cosmet Investig Dermatol. 2022;15:411–426.

13. Draelos Z. J Clin Aesthet Dermatol. 2012;5(7):53–56.

14. Allergan Aesthetics. Unpublished data. SKINVIVE? by JUVE?DERM® – 9-month duration of skin hydration in clinical trials. March 2023.

15. Allergan Aesthetics. Unpublished data. SKINVIVE? time of injection. REF-116636. October 2023.